Systemic lupus erythematosus liver damage

Systemic lupus erythematosus (SLE) is an autoimmune disease, liver damage in the combined clinical more common, caused by different reasons. Briefly as follows: 1, the major clinical manifestations Systemic lupus erythematosus induced liver injury is mainly expressed in hepatomegaly, jaundice, and abnormal liver function may exist in a variety of serum autoantibodies, etc.. Among them, hepatomegaly or about 10% -32% more than in　2-3 cm, a small number of significantly enlarged. Lupus erythematosus cause jaundice various reasons, mainly hemolytic anemia, the merger viral hepatitis, biliary obstruction and acute pancreatitis, and so on. About 30% -60% of the SLE patients have abnormal liver function tests, mainly manifested as elevated aminotransferase levels, lower levels of serum albumin, globulin levels and increased levels of blood lipids, such as. Lupus Erythematosus liver damage often mild to moderate liver dysfunction, severe liver damage are rare. Systemic lupus erythematosus can be complicated with type I autoimmune hepatitis (hepatitis lupus), will occur in younger women, can be manifested as clinical weakness, joint pain, fever, hepatosplenomegaly, jaundice, and so on. 2, identifying the reasons for liver damage Systemic lupus erythematosus patients with liver damage, we should pay attention to identifying the reasons for the cause liver damage. Some of the patients with abnormal liver function itself is not a direct result of induced lupus erythematosus. SLE with lupus itself and hepatitis can cause liver damage, but to rule out viral hepatitis, excessive drinking and liver toxicity of drugs, such as biliary tract disease. In addition, congestive heart failure, primary biliary cirrhosis, also can cause abnormal liver function. First, my viral hepatitis, particularly hepatitis B and its related diseases caused by the higher incidence rates, so patients must check the viral markers and remove viral hepatitis; Also, as caused by excessive drinking of alcoholic hepatitis are becoming increasingly more; Third, the drug hepatitis patients with SLE is also common cause of liver damage, especially because of the process used in the treatment of lupus erythematosus drug caused, including certain anti-inflammatory analgesic drugs, methotrexate (MTX) and cyclophosphamide (CTX); In addition, we should also exclude other abnormal liver function caused the disease, including biliary and pancreatic diseases. 3, pay attention to the correct treatment and monitoring Against cause liver damage in patients with SLE of different reasons, we should adopt different treatment measures. Incorrect and unscientific treatment of the disease may add to, or even after the differential diagnosis and treatment lead to greater difficulties. Currently glucocorticoid treatment of systemic lupus erythematosus is still caused by the hepatitis major lupus drug. Against Drug-induced hepatitis, if early identification, after stopping lesions often reversible. Therefore, in the course of treatment the event of abnormal liver function or jaundice, should immediately stop using the drug or suspicious, and again to avoid the same or similar chemical structure of the drug, should be in accordance with the nature of drug detoxification agent. SLE patients in each treatment period, attention should be paid to monitoring of disease activity and treatment response, in particular attention should be paid to various toxic reactions, the periodic determination of blood, urine, liver function and other relevant inspection. In short, systemic lupus erythematosus combined liver damage is very common in clinical practice, the reasons for the cause of liver damage is not the same as clinical attention should identify and timely processing.