Cirrhosis of portal hypertension caused any harm?

Portal hypertension that is portal pressure increased. Portal is the liver of a larger population of vein from the superior mesenteric vein and splenic vein convergence from the hepatic portal divided into two into the human liver. The liver's blood 75 percent from the portal vein, 25 per cent from the hepatic artery. Primarily responsible for collecting the esophagus, stomach, intestine, pancreas, gallbladder and spleen of venous blood. Under normal circumstances, portal pressure 0.7-1.5 kPa, and more than 2.0 kPa that have clinical significance. Percutaneous puncture spleen measured the pressure within the spleen can often representative of portal pressure. When liver cirrhosis or liver, portal blood flow is obstructed, may enable portal hypertension, and, congenital dysplasia, malformation or tumor suppression, and other portal pressure also increased. Hepatic Lobules these lesions may cause substantial harm, such as liver cell degeneration and necrosis, capillary network damage, followed by liver nodules and connective tissue, fibrous tissue hyperplasia. So long it will intrahepatic vascular deformation, obstruction, disruption flow deposition. When severe hepatic venous outflow obstruction, liver cells ischemia and hypoxia, increased liver cell necrosis. Intrahepatic resistance to the increase. Under such circumstances, portacaval only to increase their systolic pressure by setting enlarged blood vessels to compensate. As time goes by the formation of portal hypertension. Long-term portal hypertension caused a series of complications, such as a congestive splenomegaly, gastrointestinal, and peritoneal chronic congestive establish collateral circulation, said portal hypertension. Portal hypertension will lead to esophageal varices, abdominal and rectal varices. When the esophageal varices and reach a certain level, in the role of external factors, could break down, cause upper gastrointestinal bleeding. Performance for the large number of hematemesis or tar-like stool; rectal bleeding caused when a large number hematochezia. Portal hypertension be enlarged spleen, abdominal distension, lack of appetite, abdominal multiple organ congestion, hypersplenism. Splenomegaly and hypersplenism to RBC, WBC and platelet destruction increased, from whole blood like anemia and decreased immune function low body resistance decreased. Portal hypertension is formed ascites, peritonitis, sepsis direct factor. The appearance of ascites, and often could easily lead to insufficient effective circulating blood volume, blood pressure drop, electrolyte imbalance, involving heart, brain, kidney and other organ functions. These serious complications, at any time endangering the lives of patients.