Pregnancy and the mutual influence of acute pancreatitis

Due to the increase of uterine pregnancy, childbirth Hyperemesis Gravidarum breath and abdominal pressure, and other factors tend to have increased, with this period of high-protein,liver, gallbladder, pancreas load increased significantly, the pressure increased pancreatic duct. In addition, the fatty acid intestinal absorption capacity has been greatly enhanced, more fat accumulation that substantial increase in retroperitoneal fat necrosis may be susceptible to pancreatitis, secondary infection and abscess formation of the important factors. Worthy proposed that the syncytiotrophoblast cells of the placenta prolactin (HPL) a significant role in the decomposition of fat, triglyceride would release a large quantity of free fatty acids, which can cause pancreatic cells in acute fatty infiltration, but also caused the small arteries and pancreatic microcirculation acute fat embolism, add pregnant period of acute pancreatitis condition.
Easy pregnancy acute pancreatitis caused hemorrhagic shock, placental blood perfusion can therefore dropped sharply. At the same time, serious dehydration in the blood hypercoagulable state, the number of fibrin and fibrinogen precipitation in the placental villi blood vessels, at this time due to endometriosis is often associated with vascular inflammation, the formation of blood cells easily gather microvascular thrombosis, thus, causing vascular lacunar narrowed, thus further affecting the placenta blood perfusion. In addition, necrotizing pancreatitis, biochemical change significantly abnormal serum intermediate metabolite will lead to the accumulation of ketoacidosis. In short, pregnancy acute pancreatitis incidence of fetal distress may therefore significantly increased. There are scholars believe that the gestation period of acute pancreatitis, liver blood flow may drop more than 40%, oxidative phosphorylation, and other obstacles in energy metabolism, a decrease adenosine triphosphate, the synthetic clotting factor will decline, which will increase production in patients with acute pancreatitis during pregnancy, postpartum uterine contraction and a weakness blood from happening. Acute pancreatitis during pregnancy is not just a local pancreatic inflammation, respiratory failure because of their more complicated and heart failure and other organ dysfunction, it increased maternal perinatal mortality.