Gout complications

Most patients with gout have one or more complications, common complications include hypertension, hyperlipidemia, diabetes, obesity, atherosclerosis, coronary heart disease, cerebral vascular disease.
First, Hypertension
Gout Patients often accompanied hypertension, I Branch information for 58.8 percent. Some scholars believe that hyperuricemia and hypertension may have relevance, and that Hyperuricemia is a risk factor for hypertension, hyperuricemia are susceptible to hypertension. The reason is not clear, is the quality of the response gout, and hyperinsulinemia may be related.
Hyperuricemia the impact of hypertension: hypertensive patients such as occurred hyperuricemia, hematuria Acid Hydrolysis normal renal hemodynamic and related reflect hypertension renal vascular damage caused by the degree of renal sclerosis and serve as a hemodynamic parameters. The longer the duration, the higher the uric acid, the more severe the disease, renal blood flow more heavy damage. Its mechanism is not clear, probably by direct crystallization of uric acid deposition in sodium small artery wall and caused damage artery arteriosclerosis increase endometrial hypertension.
Hypertension on the impact of hyperuricemia: If gout patients with hypertension, can affect uric acid excretion, hyperuricemia more obvious. Hypertension is the mechanism itself may have decreased renal function caused the trend, thereby affecting the function of renal excretion of uric acid. Including: ① hypertensive renal disease can cause arteriosclerosis; ② angiotensin hypertension, elevated catecholamine concentrations, renal blood flow reduction, tubular hypoxia increased lactate formation, the latter on uric acid excretion competitive inhibition to reduce uric acid secretion, the effects of renal excretion of uric acid, making into uric acid retention; ③ long-term use of certain patients with hypertension such as Thiazide diuretics, triamterene Pteridine, but also the impact of tubular excretion of uric acid, uric acid emission reduction.
In short, hypertension and gout may mutually some reason, mutual promotion, hyperuricemia and hypertension at the same time caused by the existence of different levels of atherosclerosis and renal sclerosis common renal blood flow leading to the reduction and deterioration, thereby increasing the development of the illness. But its exact relationship to be further studied.
Second, hyperlipidemia
Homoharringtonine hyperlipidemia or triglyceride (TG) and hyperlipidemia significantly increased serum uric acid related. According to the information I Branch, gout patients with 75% to 80% with hyperlipidemia. While patients with hyperlipidemia 60 percent to 80 percent with hyperuricemia. Serum uric acid and triglyceride numerical significant positive correlation. Some scholars believe that the third year triglycerides decreased renal excretion of uric acid is one of the reasons for gout.
Third, diabetes
Gout patients is often associated with Iridium chain spectrum N dobsons persimmon deck Yun Jing? Gout with diabetes - 8.6 percent. Gout and diabetic there are many common factors, such as age, obesity, and so on. Like human blood glucose values as uric acid, with the increase of age have increased tendencies. Some scholars believe that the excessive concentration of serum uric acid can directly damage the pancreas J3 cells, and induced diabetes. Even some patients with gout increased insulin antibody diabetes.
Conversely, patients with diabetes easily generate hyperuricemia. Decomposition of purine metabolism and increased uric acid production increase is diabetic characteristics. Diabetic patients in hyperuricemia can be divided into three types: type metabolism, kidney-type, mixed. Metabotropic features have increased uric acid in the body, kidney type is characterized by lower renal excretion of uric acid, mixed type is characterized by the formation increased uric acid excretion and reduce both. Hyperuricemia in the formation of kidney factors often is of great significance. Hyperuricemia almost all the diabetic patients have chronic renal insufficiency, and the characteristics of renal excretion of uric acid damage. In type 1 diabetes incidence hyperuricemia, kidney damage play a major role. Type 2 diabetes hyperuricemia composite factor is the occurrence of the decision, that is, kidney damage and function of increased uric acid formation.
4, obesity
Gout was particularly prevalent in the obese. Obesity is defined as artificial, the majority of the current standard weight as the basis. The standard weight (kg) = height (cm) -105, or height (cm) -100 later by the 0.9 (male) or 85 (women). Weight exceeded the standard body weight 20 percent for obesity, and in 10% ~ 20% for overweight.
Obesity may cause hyperuricemia and endocrine system disorders or in vivo - generated inhibit excessive uric acid excretion related. Obesity energy intake increased, purine metabolism can also lead to accelerated serum uric acid concentrations increased. Some studies show that overweight or obese Mean serum uric acid and hyperuricemia detection rate were significantly higher than those of normal weight or low. Overweight or obese than those of normal weight or below the standard weight, easy existence of sugar, fat and protein substances such as metabolic disorders, the risk of gout, hypertension, hyperlipidemia, and diabetes and other diseases. Thus the prevention and treatment of overweight and obesity in these substances to improve metabolic abnormalities useful so that they could reduce gout, hypertension, hyperlipidemia, and diabetes prevalence rate. Total weight loss also invaded blast torsion chuiwan high plane trip Т practicing ┲? One?
5, coronary heart disease
According to the information I Branch, gout patients with coronary artery disease for 15.6 percent.
Some scholars will hyperuricemia as one of the risk factors of coronary heart disease. Some even call it "gout" heart disease. But whether hyperuricemia can be used as the risk factors of coronary heart disease is still controversial, uric acid and other scholars believe that the occurrence of coronary heart disease, cardiovascular disease mortality was no causal relationship.
Conversely, patients with coronary artery disease may exist uric acid metabolic disorders, and often associated with higher serum uric acid. The reason is not clear, some academics have found blood insulin resistance in patients with coronary heart disease although the index was higher, but the insulin resistance index and not obvious correlation between serum uric acid, showed that insulin resistance may not be the main reason for uric acid metabolic disorders.
6. Cerebral infarction
Gout with cerebral infarction rare, accounting for only 2.1 percent.
In short, because of gout was particularly prevalent in the elderly, and is often associated with obesity, hypertension, hyperlipidemia, diabetes, atherosclerosis, coronary heart disease, cerebral vascular disease, and so on. The above several diseases associated with hyperuricemia of strong, but all of these factors will combine perfect is difficult, hyperuricemia these diseases may not be an independent risk factor, and multiple factors. Like hypertension affect the renal excretion of uric acid, uric acid intake obesity more acidic metabolites competitive inhibition of tubular excretion of uric acid, diabetes increased catabolism of purine and uric acid production increase. The pathogenesis,
Hyperuricemia often associated with these risk factors more or less together, the incidence of gout and progress plays a synergy. It that the above factors may be common, casual, constitute incidence trend. But hyperuricemia and obesity, hypertension, hyperlipidemia, diabetes, atherosclerosis, coronary heart disease, cerebral vascular disease, bringing together the pathological basis of what this phenomenon will be gathered, what are intrinsically linked? Family of genetic factors on the number of such contacts from the role? These mutual the precise relationship is not yet clear, it is worth further exploration.
In the treatment of primary gout was found along with the decline in the level of serum uric acid and gout symptoms eased, with the incidence of certain symptoms such as angina, chest tightness, lightheadedness, heart palpitations, headache, and so obviously improved. Some unused hypolipidemic drugs in patients with high blood lipids, blood uric acid level with the effective control lipids decreased significantly. Some refractory diabetes, blood glucose also decreased significantly. Therefore, as purine metabolism disorder is the primary gout coronary heart disease, hypertension, diabetes, hyperlipidemia deterioration factors, the timely control gout, with the incidence of their control is also very useful. Therefore, I believe that the primary diagnosis for patients with gout should conduct routine blood lipids, blood sugar, ECG, X-ray and other inspection, with early detection of disease. As for the above patients with the disease need to repeatedly check serum uric acid and urinary uric acid, timely treatment of hyperuricemia.