Hyperlipidemia which endanger the patient?

(1) glomerulosclerosis, etc.: hyperlipidemia can cause vascular endothelial cell injury and
kitchen-off, resulting in increased vascular wall permeability, plasma lipoprotein was able
to get into the vessel wall and endometrial deposition was caused macrophage response and
the removal of vascular smooth muscle cell proliferation and form plaque, and I. caused by
arteriosclerosis, renal atherosclerosis, luminal stenosis can occur renal ischemia,
atrophy, interstitial fiber hyperplasia. If renal vascular occlusion is the corresponding
region infarction, infarction after formation of scar. This led glomerulosclerosis. In the
kidney, may accelerate the occurrence of coronary sclerosis, resulting in patients with
coronary heart disease and increase the risk of myocardial infarction. Similarly, while
other parts of arteriosclerosis caused by the corresponding diseases such as cerebral
arteriosclerosis, cerebral infarction, and so on.
(2) glomerular injury: hyperlipidemia may cause lipid deposition in the glomeruli, low-
density lipoprotein cycle can be activated monocytes and lead glomeruli infiltrating
mononuclear cells, and caused or exacerbated inflammatory response, while the glomerular
mesangial cells, endothelial cell activation can produce molecular oxygen, the promotion of
lipid peroxidation, oxidation of low-density lipoprotein (OX-LDL) are extremely cytotoxic
effects, leading to kidney damage. In addition, hyperlipidemia can arouse mesangial matrix
collagen, laminin and fibrin increase, and these components are directly related
glomerulosclerosis.