Hepatitis cirrhosis and liver cancer relations

Hepatocellular carcinoma (HCC) is one of our common malignancy, or cancer mortality second place. Nearly a dozen years since the diagnosis and treatment of liver cancer in the original level on the basis of a greatly improved, and has made noteworthy achievements. First, the relationship between hepatitis and liver cancer Large epidemiological investigation and experimental study has proved B, hepatitis C and closely related to the occurrence of liver cancer. This has been recognized by the people, but so far its carcinogenic mechanism is not clear. HBV carcinogenic mechanism, in the past was that HBV genome contained oncogene views have long denied. After activation of HBV integration on the promoter or the mechanism of enhancer not be confirmed. In recent years that X gene and closely related to the occurrence of liver cancer; HCV is an RNA virus, according to recent study found that HCV core protein in vitro have the potential carcinogenic effect. The clinical findings, the majority of liver cancer patients have hepatitis and cirrhosis past history. Cirrhosis of liver cancer occur in those 15% -25%, generally around 20 percent, the majority of hepatocellular carcinoma in hepatitis cirrhosis basis happen. Second, how to evolve into liver cirrhosis liver cancer? Hepatitis is the main pathological changes in liver inflammation, necrosis and fibrosis, and some degree of necrosis heavier debris such as necrosis, bridging necrosis, followed by the Department of liver fibrosis district to enter into Hepatic Lobules, gradually forming false lobule, a renewable nodules. The occurrence of liver cancer nodules and regeneration closely related. Most scholars believe that adenomatous hyperplasia of liver cancer precancerous lesions, the multi-step evolution of liver cancer: large renewable nodules - adenomatous hyperplasia - atypical adenomatous hyperplasia - adenomatous hyperplasia deterioration of liver cells with a small number - well-differentiated (Level I) in the early liver cancer. Most of the incidence of liver cancer summarized as follows: HBV, HCV, alcohol, other - chronic hepatitis (inflammation, necrosis, fibrosis) - liver cirrhosis (nodule formation of different types of change, adenomatous hyperplasia) - HCC