Primary chronic adrenal hypofunction Diagnosis

Clinical manifestations: 1. Skin pigmentation, weak weakness, anorexia, weight loss, low blood pressure, vertical syncope, cardiac narrowing, women　and pubic hair scarce or exfoliated;
2. Tuberculosis may have fever, night sweats, pulmonary tuberculosis and adrenal calcification imaging;
3. Stress (trauma, infection, etc.) or abrupt discontinuation of hormone replacement therapy can be induced adrenal crisis, there may be nausea, vomiting, syncope, shock, coma.
Diagnosis: 1. Skin pigmentation, general weakness, dizziness, anorexia, weight loss, low blood pressure, vertical syncope, cardiac narrowing, women　and pubic hair scarce or falling out of tuberculosis may have low heat, night sweats;
2. Blood eosinophils, lymphocytes increased pigment is mild anemia, a small number of merger pernicious anemia, reduced neutrophil;
3. Hyponatremia, hyperkalemia, low blood glucose, glucose tolerance test was　curve;
4. Plasma cortisol and 24-hour urinary free cortisol lower;
5.24 hour urine 17 hydroxybutyrate corticosteroid, 17 ketones reduce steroid content;
6. Increased plasma ACTH, ACTH stimulation test no obvious reaction;
7. Chest and abdominal X-ray film can be found signs of TB, positive tuberculin test;
8. Adrenal CT and MRI lesion can be found.