Nephrotic syndrome and the relationship between hyperlipidemia

Patients with nephrotic syndrome in hyperlipidemia mechanism are still not clear. Often
patients with nephrotic syndrome resulting from the large number of urine protein plasma
protein decreased, hypoproteinemia may be compensatory to make the protein, in particular
lipoprotein such as very low density lipoprotein (VLDL) accelerated the synthesis, which
can be converted into low-density lipoprotein (LDL), thereby increasing LDL, it can be that
is the reasons for the formation of hyperlipidemia.
Therefore, the majority of patients with nephrotic syndrome increased plasma lipid, or even
a fasting plasma can emulsion. Although a variety of blood lipids can be increased, but the
largest increase in the neutral fat, cholesterol and triglycerides are increased, the
extent of its decline and plasma albumin was negatively correlated. Early blood cholesterol
greater than 7.15 cents mole / liter, serious increased to 25.86 cents mole / liter or so,
the proportion of cholesterol and phospholipids average increase to 1.28 (average normal
value of 0.95). Patients with yellow skin can be a tumor.
Nephrotic syndrome hyperlipidemia continued for too long, there may be atherosclerosis,
thrombosis and embolism. Researchers have observed that patients with chronic renal
insufficiency triglyceride synthesis of normal lipoprotein lipase activity decreased
triglyceride decomposition obstacles at the same time, because of chronic renal
insufficiency in patients with increased serum triglyceride levels, the incidence of
vascular lesions increased, therefore we have to seriously treating hyperlipidemia.
However, these patients with hyperlipidemia response to poor diet therapy should be used in
combination with the bile acid resins and nicotinic acid lipid-lowering treatment.