Lead poisoning

Since taking over lead poisoning lead acetate, lead carbonate, chromium Lead acid, tetraethyl lead and the breathing dust or smoke, steam and skin absorption of oral or its solvent and poisoning. Excessive exposure, inhalation of lead or lead compounds herbs such as Zhang Dan, and Dan tin, sheep epilepsy crazy things, and the use of leaded cosmetics can also cause poisoning. Acute lead poisoning mechanism, mainly lead and lead compounds into cells with the enzyme sulfur binding, inhibiting enzyme function. While the obvious damage to the central nervous system, can interfere with the synthesis of hemoglobin, caused porphyrin metabolism. Lead role in the cell may cause hemolysis, and the emergence blood, nerves, digestive, urinary system, and a series of symptoms. The clinical manifestations of acute lead poisoning: 1. Digestive system performance such as nausea, vomiting, loss of appetite, mouth metal taste, salivation, abdominal distention and constipation, blood in the stool, abdominal cramps and-by, but also with hepatomegaly, jaundice and liver dysfunction such. 2. Nervous system performance for the headache, dizziness, trouble deeply disturbed, insomnia, somnolence, easily agitated may have severe delirium, convulsions, seizures, coma and even cerebral edema and peripheral neuritis performance may also arise. 3. Blood show was pale, heart palpitations, shortness of breath and other symptoms of anemia. 4. Urinary symptoms are pain, edema and proteinuria, hematuria, possession of urine, can be a serious kidney failure. Adults often happened after lead poisoning: fatigue, emotional depression, heart failure, abdominal pain, kidney deficiency, high blood pressure, joint pain, reproductive barriers, anemia and other symptoms. Lead poisoning pregnant women will arise after abortion, low birth weight neonates, the dead child, infant development and other serious adverse consequences. While children often happened: loss of appetite, stomach, insomnia, learning disorders, constipation, nausea, diarrhea, fatigue, low IQ, anemia and other symptoms. Lead poisoning hazards in the performance of the main nervous system, blood system, cardiovascular system, skeletal system and the harm of life: Lead right over central and peripheral nervous system in specific neural structures have direct toxic effects. In the central nervous system, cerebral cortex and cerebellum of lead toxicity is the major target organizations; In the peripheral nervous system, the motor nerve axons Lead poisoning is the main target tissue. Which lead on the nervous system toxicity is mainly expressed in the following four types: (a) to lead the psychological changes, such as adult lead poisoning after a depression, irritability, personality change symptoms, and that the children are more dynamic performance. (2) will lead to mental decline of lead poisoning, especially in children learning disabilities, it was reported high lead children lower than the average IQ of children with low lead at 4-6. (3) will result in lead poisoning feeling dysfunction, for example, many patients will lead the visual dysfunction: retinal edema, the ball after optic neuritis, blind spots, outreach eye muscle paralysis, optic atrophy, and eye movement disorders, abnormal pupil adjustment, or amblyopia vision changes; or smell, taste disorders. (4) Lead the peripheral nervous system is to reduce the impact of major motor function and nerve conduction velocity, lead poisoning is a serious muscle damage that a typical one. Blood lead on the main role in the performance of two parts: One is inhibiting the synthesis of hemoglobin, two is to reduce the life cycle of RBC, these effects will eventually lead to anemia. Lead hurt the cardiovascular system performance in the main: (1) cardiovascular disease mortality and excessive lead in the artery closely related to cardiovascular disease and 24-hour urine blood lead levels were significantly higher than the non-cardiovascular disease. (2) Lead exposure can cause hypertension. (3) Lead exposure can cause a heart attack and cardiac function. Bone lead is a major target organ toxicity, lead one through injury endocrine organ function and indirectly affect bone metabolism and bone mineral regulation, on the other hand through the poison cells, the basic cells interfere with the process and enzyme function changes osteoblasts - osteoclasts coupling relations and the impact of calcium from the system direct interference bone cell function.