Why corticosteroid asthma can effectively control?

Glucocorticoids, primarily through the following channels play a role in order to achieve the purpose of the prevention and treatment of asthma. (1) of glucocorticoids can effectively prevent or reduce allergic airway inflammation and lower airway from allergic inflammation induced airway hyperresponsiveness anti - Ying Xing. The present view of the pathogenesis of asthma not only by certain allergens or incentives caused by bronchial spasm (contraction) of the causes . but due to allergens or other factors (external), and body inherent in the Constitution (specific) reactivity physique (internal), Interaction of a series of allergic reactions occurred in allergic airway inflammation (reaction). Regardless of asthma exacerbation or remission, regardless of the severity of allergic airway inflammation persists, cause the airway to outside stimuli response increased (airway hyper-responsiveness), Once exposed to the normal reaction is not a slight boost, it will cause extensive airway spasm (narrow), increased mucus secretion, the patient felt tightness in the chest, sputum increased, cough and asthma and other acute asthma attack. Glucocorticoids on the trigger allergic inflammation lesions of the many elements involved in the pathogenesis of asthma and the inhibition of inflammatory cells have available. Recently found that inhaled corticosteroids can prevent various inter-induced bronchoconstriction and airway hyperresponsiveness in asthma late (delayed ) reaction, if long-term use will also reduce all of the early antigen (speed) reaction and exercise-induced asthma. Glucocorticoid the strongest anti-inflammatory effects, the results would be the best, while both permanent cure the symptoms. (2) of glucocorticoids can effectively increase β2 agonist (eg salbutamol or CHUANKANG speed, etc.) the expansion of bronchial role. Modern β2 agonist is the most commonly used asthma medicine, as a result of successive applications, The response of patients gradually decreased (medically known as desensitization or tolerance), it is also more effective not fall, Glucocorticoids through increased airway beta receptor density of airway smooth muscle beta receptor response stop and reverse beta agonist sensitivity of the rapid decline. Glucocorticoids can prevent a lot of smooth muscle contractile properties of the medium formation and release. (3) corticosteroid with anti-allergic (immune suppression), it will inhibit lymphoid hyperplasia, make blood lymphocytes of special T-lymphocyte reduction, but also inhibit the specific IgE production. (4) glucocorticoids can significantly improve airway obstruction and arterial oxygen, conducive to severe acute asthma attack (asthma status) of the safety of our patients to ride out the storm.