Sarcoidosis

Sarcoidosis (sacoidosis) is a not-for the multi-system granulomatous disease. The most common organ involvement with the lung, 90% of lung changes, followed by skin and eye lesions, superficial lymph nodes, liver, spleen, kidney, bone marrow, nervous system, heart and other systemic almost every organ can be involved. Since the disease was limited to mostly good prognosis, mitigation of natural trend. But clinical need and other granulomatous diseases such as tuberculosis, beryllium disease and some interstitial lung disease were identified. The disease more common in middle-aged 20-22 --40-year-old accounted for 55.4% of the total number of patients. The incidence of men and women roughly equal. [Clinical] 1. Misprision of incidence. Fever, night sweats, fatigue, weight loss. 2. Cough, cough-based, there are expectoration, unconsciousness, chest pain, shortness of breath, spontaneous pneumothorax. 3. Skin rashes, joint pain, hepatosplenomegaly, superficial lymphadenopathy. 4. Eye disease (conjunctivitis, retinitis, cataract, iridocyclitis). [Diagnosis] 1. Chest imaging examination showed bilateral hilar and mediastinal lymph node enlargement symmetry, with or without pulmonary mesh, nodular or flake shadow. 2. Histological biopsy confirmed that the non-caseating granulomas necrosis, and acid-fast staining negative. 3. SACE serum angiotensin enzyme activity than increased. 4. Serum or in BALF IL-- 2 receptor (IL-2R) level increased. 5. The old tuberculin (OT) or PPD test was negative or weakly positive. 6.BALF number of lymphocytes in> 10% of CD4 and / CD8 ratio> = 3. 7. Hypercalcemia, high urine disease. 8.Kveim test positive. 9. Except for tuberculosis or other granulomatous disease. The nine, 1,2,8 as the main indicator for the other secondary indicators [Auxiliary] Chest imaging examinations (X-ray or CT) is necessary to the inspection, conditions should be possible for lung biopsy, fiberoptic bronchoscopy and bronchial lavage checks to clear diagnosis, SACE, there are some Kveim test diagnostic value.