Prostate cancer endocrine therapy

Use of endocrine therapy to conquer prostate cancer, can play through different channels efficacy to achieve : ?٠removing androgen sources. ?ڠinhibit pituitary release of luteinizing hormone. ?۠inhibiting steroid synthesis. ?ܠin the target tissue androgen suppression role. Endocrine therapy : (1) of testicular resection : Androgen can make prostate cancer cells proliferated, the use of bilateral Koo pill for the treatment. Clinical commonly used in prostate cancer patients with metastatic cancer, the survival rate after five years of 31%, metastasis to 20%. Testicular resection has the advantage of the body can get rid of androgen the main source, the body does not increase another hormone, not taking estrogen after the anemia, cardiovascular disease and the occasional occurrence of liver failure and other side effects. There is no patient will not adhere to the long-term medication, once and completed treatment. (2) estrogen therapy : Estrogen can inhibit secretion of the prostate body, it gland in a state of contraction. Therefore, the clinical use of estrogen treatment of prostate cancer. The most commonly used drug is diethylstilbestrol, daily 2 ~ 15 mg oral dosage gradually increase, daily until 30 ~ 50 mg produce far. Or start with a large dose of daily 50 ~ 100 mg of oral or intramuscular injection. When large doses to prevent sodium and water retention, security, as appropriate, taking spironolactone, roughly 1 mg daily. The cure rate is 25%. Ethynylestradiol, a daily ~ 3 mg oral. Poly estradiol phosphatase, 80 ~ 200 mg daily intramuscular injection once. (3) anti - androgen therapy : Many common drugs, such as a meeting of two methyl chloride to melengestrol acetate, phosphate estrogen nitrogen mustard, Amino can I. Mian, An Ti spironolactone, which requires application under the guidance of a doctor, have a certain effect. (4) adrenocorticotropic hormone therapy for adrenal hormones can inhibit adrenal androgen produced, Therefore, for the treatment of prostate cancer can improve the general situation, can be used as palliative therapy.