The disease induced by factors of gastric cancer

1. Gastric ulcer Can cancerous ulcer on the issue, there have always been different views on the controversy. Many people think that the majority of the occurrence of cancer has nothing to do with ulcers. However, clinical studies or pathology can be seen, the incidence of gastric ulcer and gastric cancer have a certain relationship. Domestic reported stomach ulcer The cancerous ulcers rate of 5 ~ 10%, especially long history of gastric ulcer and middle-aged and older patients with a greater chance of cancer, the ulcer edge of the epithelium or gastric glands erosion caused by erosion, destruction and regeneration in the repeated chronic stimulation into cancer. After subtotal gastrectomy for gastric cancer incidence rates than the general population is higher in the past has been the importance of workers. 2. Chronic gastritis According fiber gastroscopy seen mucosal morphology, can be divided into chronic superficial gastritis, atrophic and hypertrophic three. Now recognized atrophic gastritis is an early gastric cancer lesions, especially with gastric or intestinal polyps at the same time the presence of adenovirus, chemical and biological weapons more likely. Superficial gastritis can be cured, but there are also likely to change gradually as atrophic gastritis. Hypertrophic of gastritis and gastric cancer incidence little. Atrophic gastritis difficult to cure, the organization renewable trend, sometimes forming polyps, and sometimes cancer. Long-term follow-up tracking can be found in atrophic gastritis carcinogenesis reached about 10%. Comprehensive study of the materials of gastric cancer, gastric cancer and the high incidence area of superficial atrophic gastritis cases of gastric cancer significantly lower than the district. Patients with chronic gastritis high incidence area of fasting gastric analysis suggested that lowering free acid content, pH value, the number of bacteria, NO2 concentration of nitrate-reducing bacteria, as well as the detection rate increased, and low compared to areas with significant differences. The intragastric environmental change and the degree of chronic gastritis and the severity of disease was positively correlated also shows that patients with chronic gastritis gastric environment has changed, very beneficial to the N-nitroso compounds synthesized. 3. Gastric polyps Benign tumors are malignant gastric any possible, and the epithelial malignant adenomas, or polyps more opportunities. More than 2 cm in diameter in the polyps, cancer incidence increased. There are reports of the X-ray diagnosis of patients with gastric polyps, with some 20% of malignant transformation; In gastric polyp resection specimens, see 14% of multiple polyps are malignant, 9% of a single malignant polyps, which explain all the X-ray diagnosis of gastric polyps are not easily let go Case . 4. The gastric intestinal metaplasia The inherent means of gastric mucosal epithelial intestinal epithelial cells into the phenomenon, in the light of only a small number of pyloric Department of intestinal epithelial cells, the heavy involvement of a wide range of full-thickness mucosal thickening, and even gastric body also false intestinal villi form. The intestinal metaplasia glandular lesions may represent harmful substances caused by the stimulation of gastric dysplasia (also known as the inter-change). If stimulate persistence, metaplasia state can continue to exist; If after proper treatment, the state can resume normal metaplasia or completely disappeared, so mild gastric intestinal metaplasia gland could not be considered a pre-cancerous lesions. Sometimes the intestinal metaplasia glandular epithelial hyperplasia than normal amount of changes, such profiled epithelial dysplasia development of the serious, such as inter-?󠣨ange can be seen as pre-cancerous lesions.