Toxoplasma infection and infertility.

Sexual intercourse by the spread of the disease known as total sexually transmitted diseases, including gonorrhea, syphilis, chlamydia, mycoplasma infection and toxoplasma infections. These diseases, and some can cause tubal obstruction, caused some endometritis, uterine muscle wall damage, other endocrine dysfunction and infertility; Some important cause organ damage and endanger lives; Some of the illness can occur during pregnancy abortion, premature or stillbirth. Toxoplasma infection called toxoplasmosis Toxoplasmosis is a parasitic infection widely distributed around the world. Residents in some countries the infection rate is as high as 20% to 80%, China has 19 provinces, municipalities and some residents of the autonomous region screening positive rate of 5.17%. ??Pathogens -- for the cause toxoplasmosis, a parasite that cats to end host, the parasitic growth cats multiply. In the acute stage of infection of the cat form of parcels, their eggs in the intestine cat with cat feces discharged. Other livestock muscle, may also have Toxoplasma cysts. Human infection prevalence of oral pathogens or food-induced egg. It was transmitted through the following channels : ?٠puffiness fresh meat, fresh means of Toxoplasma cysts; ?ڠdrinking contaminated water or inhaling droplets of infected animals droppings; ?۠contact touching infected cats; ?ܠvegetables or utensils were contaminated cat feces. ??Clinical manifestations -- 103 through the placenta to the fetus, embryo death or teratogenic, more harmful to humans. Toxoplasma in parasitic cells and proliferation, resulting cell has been destroyed, tachyzoites escape after violations of the neighboring cells, such repeated damage, resulting in the inflammatory response, edema, mononuclear cells and a few multinucleated cells infiltration. Toxoplasmosis can be spread by blood violations of various organs and tissues. Toxoplasma antibody widespread in the population, but clinical Toxoplasma patients so rare. Note the vast majority of infections are asymptomatic. Clinical toxoplasmosis can be divided into congenital and acquired two. 1. Congenital toxoplasmosis by placental transfer, the only mother in the protozoa hyperlipidemia. Before the mother during pregnancy toxoplasmosis infection, generally not transmitted to the fetus. According to reports, the pregnant mother who was infected, about 50% of the fetus to be congenital infections. Pregnant early and mid-infected persons, in addition to causing a miscarriage, it can also cause multiple fetal deformity, such as hydrocephalus, no brains water, small eyes, no eye disease, congenital cataracts, cleft lip and palate, congenital heart disease, imperforate anus and limb malformations. Infection in late pregnancy, premature births, stillbirths, stillbirth and early neonatal deaths, maternity patients with congenital acute Toxoplasma abuse, delivery of congenital toxoplasmosis at quiescent newborns. After infection can often survival of children with congenital brain damage left over from epilepsy or mental stunting. Part of congenital infection in infants without symptoms but only for the performance of serum antibody positive, such infants in adult emerged after chorioretinitis. Infected mothers in the middle of the next fetal congenital infection of infants, because they have become chronic infection, it is a rare meeting again fetal congenital infection. 2. Toxoplasmosis was the most common manifestations of lymphadenopathy, harder, rubber-like flu, accompanied by a long period of low heat, fatigue, muscle discomfort in some patients with splenomegaly temporary, occasional sore throat, headache and skin spotted or pimples. Violations such as Toxoplasma other organs can corresponding symptoms, such as myocarditis, pneumonia, encephalitis etc.. There are very few adult patients chorioretinitis. A diagnosis. Epidemiological data contact with sick animals or history, or organ transplantation, blood transfusion, contact with contaminated items immature and eating the meat, milk, eggs and other foodstuffs. Congenital infection, the mother of patients. 2. Auxiliary inspection (1) direct microscopy : France's Giemsa staining or after the Wright investigation toxoplasma. (2) animal inoculation method : from the patients body fluids or tissue fragments, and saline dubbed 1:4 suspension, admission 0.5 -- was tube-fed mice injected intraperitoneally, about one to three weeks, from the mouse peritoneal exudate for inspection Toxoplasma can be detected. (3) Artificial Cultivation : monkey kidney cells or pig kidneys were collected from adipose media organizations, after inoculation Toxoplasma may, in its growing. Including : serological and immunological screening; Sabin-Feld - nan's coloring test; inding test; indirect fluorescent antibody test and indirect hemagglutination test; immunofluorescent antibody test, enzyme-linked immunosorbent assay. A treatment. Spiral adriamycin : Adult volume 4 ~ 5g / d, in four oral ,10-14 days for a course of treatment, 1 ~ 2 weeks after a course of treatment. 2. Abciximab : Teratogenic Effects, pregnant women with caution. Adult dosage of 25 mg / d. 3. L-blind Study : 150 mg / d, and even served as a course of 3 days, two on each serving a two-week course of treatment. 4. Sulfadoxine-pyrimethamine with the joint application, efficacy increased eight-fold. 5. Adrenal cortical hormones : for severe toxemia, and toxoplasmosis caused the retina, choroid, iridocyclitis and serious hepatitis, nephritis. While attention to the treatment of toxoplasmosis to give the medicine. In short, the treatment of the disease are : non-use of these drugs during pregnancy treatment; As early as pregnancy, illness should be held in mid-abortion, induction of labor; late pregnancy prevalence of these drugs are used, it should be noted side effects. However, in order to reduce the incidence of the disease, should strengthen prevention measures to cut off transmission.