Friday, January 11, 2008

Infection and habitual abortion

The infection during pregnancy are not only harmful to the mother, some infections can fetus and newborn to have a serious impact. In addition to possible miscarriages, premature or stillbirth, but also to the various deformities and mental retardation of children, thus affecting the quality of the population. Pathogens and disease -- a mechanism. TORCH TORCH syndrome as a group to infection during pregnancy mainly of microorganisms, production through the placenta or intrauterine infection caused Road, lead to miscarriage, stillbirth or fetal growth retardation, deformity, even neonatal infection and / or puberty barriers, known as TORCH syndrome. It mainly refers to the following pathogens : Toxoplasma gondii (T), rubella virus (R), cytomegalovirus (C), herpes simplex virus type I and type II (H), other virus (O) : Coxsackie virus, hepatitis B virus, choroidal lymphocytic meningitis virus. The mother suffering from toxoplasmosis, the body can be menstrual blood to the placenta running clearance pass the fetus, so that it infected. Initial infection during pregnancy can lead to serious miscarriages, premature fetal deformity or fetal death. Rubella virus infection occurred in the past 20 weeks pregnant, the incidence of fetal malformation high. Maternal rubella infection, rashes in there a few days ago, there viremia, was disseminated multiple organ infection, caused severe fetal death, spontaneous abortion cause. Other viruses caused by intrauterine infection can also cause miscarriages, stillbirths and malformations. 2. Some scholars believe Mycoplasma Mycoplasma genitalium infection can worsen during pregnancy, staying in the reproductive tract of Mycoplasma can type the risk of spontaneous abortion increased. Mycoplasma infection causes abortion and Mycoplasma can be 21, 22 pairs of human chromosome deletion of the short arm of the, resulting embryos chromosome structural changes that are occurring abortion. Diagnosis -- TORCH syndrome, mycoplasma infection is not necessarily a serious symptoms, lab testing is therefore an important means of diagnosis. 1. Toxoplasma used indirect hemagglutination inhibition test, the indirect fluorescent antibody method and indirect latex agglutination. 2. Rubella virus hemagglutinin inhibition test titer in l : 256 more should be further determination of rubella IgM and IgG antibodies, incidence four days the two were positive for IgM advantage after IgG increase gradually gaining an advantage. 3. Other pathogens can be detected through urine and cervical secretions for pathogen isolation; Complement fixed and hemagglutination inhibition test; Detection of specific IgM. Suspected mycoplasma infection for mycoplasma culture. Control -- one. Toxoplasmosis TOXIgM where maternal serum positive, the note is the recent infection, it should be applied as soon as possible Acetylspiramycin 1.0g, 4 / d, oral 14d; also available oral doxycycline treatment. Detection of Toxoplasma negative should strengthen prevention, including eating, no contact with the dogs and cats, blue-meat, cooking thoroughly cleansing. 2. Rubella infected with rubella virus, there will be lasting immunity, using live rubella virus vaccine for the prevention of preventive vaccination is the primary means of rubella, rubella virus infection has been available for treatment of interferon. As of early pregnancy rubella virus infection, with particular attention to the monitoring of the fetus. 3. Cytomegalovirus cytomegalovirus infection of primary and recurrent infections can be long-term or intermittent detoxification, currently there is no safe and effective protective vaccine. Therapeutic use of purine and pyrimidine derivatives antiviral and interferon, transfer factor. 4. Mycoplasma doxycycline, tetracycline, lincomycin and spectinomycin and its efficacy, under conditions selected.

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