Habitual abortion autoimmune treatment

Right and immune factors relating to the customary abortion patients or unexplained habitual abortion patients can be immune therapy : immunotherapy 1981 from Beer and Taylor Alliance. Right autoimmune habitual abortion patients, using her husband or others for the same types of lymphocytes sensitized treatment, strengthening pregnancy maintain immunological mechanism of inhibition of maternal-fetal cell immune rejection, to reduce the abortion rate, the efficacy of up to 70-90%. (1) Immunotherapy adaptation levy : 1, no clear reason for the early habitual abortion; 2. no blood contained antibodies; three couples have two or more than two of the same HLA antigens, I and type II antigens compatibility> 5, II antigen-> 4, or anti-D / DR antibody; 4. no anti-drug patrilineal lymphocyte antibodies; 5, the right man with a one-way mixed lymphocyte reaction. a third party unrelated to the response to antigen stimulation; 6, the couple agreed to accept immunization treatment. (2) the treatment of an immune-enhancing, immune original use her husband's lymphocytes, third party blood lymphocytes or monocytes, and methods for : her husband's blood heparin separation, Wash the wave of lymphocytes for injection, use a condensed WBC or whole blood for intravenous injection. 200radX ray irradiation using inactivated, then intradermal injection can be reduced versus host reaction. 2, immune-enhancing immune therapy treatment time : in the first trimester of pregnancy, pregnancy, it is advisable to pre-pregnancy, during pregnancy to 40 days for good results. Commonly used methods : pregnancy before the immunization 2-4 times at intervals of two weeks, the first six weeks of pregnancy before and after immunization 1-3 times. ?٠lymphocyte injection : spouse whole blood lymphocytes, and concentrated to 3-4 × 107/mL, every 2-4 weeks to his wife bilateral forearm skin or subcutaneous injection points, each point every 0.3-mL, aids or intravenous injection, immune to 3-5 times. ?ڠmicrocosm of the cell : with the concentration of leukocytes from the liquid can be used as a closure for lack of antibodies to the habitual abortion. Starting from pre-pregnancy every three weeks with an intravenous 400 million leukocyte plasma or whole blood 250mL husband, the hours lost 1-2 End until 27 weeks of gestation date. ?۠preparation placental trophoblast immune therapy; The use of placental trophoblast organization with a similar interleukin immunogenicity of the characteristics 1 g wet weight of the same blood type trophoblast agents (about 100 mg total protein) plus saline 250mL, to avoid the slow drip 1-2 hours after treatment from January to March without cytomegalovirus antigen antibody before pregnancy. (3) passive immunization with anti-immunoglobulin placental trophoblast unique antigen-antibody and anti-idiotypic antibodies, for its own anti-idiotypic antibody shortage of habitual abortion. Method : Preconception 0.5mg/kg / month, five weeks pregnant when a treatment, the dose of 500-600mg/kg. then once every two weeks, the dose 300-400mg/kg until 22-24 weeks pregnant. (4) immunosuppressant used mainly for anti-sperm antibodies, APA and other autoantibodies positive and autoimmune diseases habitual abortion patients. A low dose of maintaining law : Strong pine 5mg, 1-3 times daily, 3-12 months; 2, the high-dose technique : methyl hydride test Pine 98mg / d total of seven days, or prednisone 10 mg / d, a total of seven days. 3, vaginal topical medication; The pine hydrocortisone 10 mg / d, 6 months. 4, suffering from autoimmune diseases and habitual abortion, available prednisolone 30 mg / d. (5) Other therapy primarily to the APA-positive patients habitual abortion. 1, heparin therapy; 2, low-dose aspirin + prednisone; 3, condoms therapy.