Friday, January 11, 2008

Endometriosis the pathogenesis

Endometriosis is a complex and difficult diseases. Ectopic occurred in the pelvic organs, but also appeared in the pleura, lungs, navel, limbs, muscle, meninges, the pericardium and other places, due to ectopic extensive, the medical profession believes that the disease is caused by a variety of causes integrated. One, menstrual blood backlash, endometrial implantation. Menstrual period of menstrual blood from the mouth Palace, vaginal discharge is outside the body downstream, However, a small number of menstrual blood or other reasons coupled with endometrial shedding of debris from tubal Road flow into the abdominal cavity, planted in the pelvic organs formed on the surface of endometriosis lesions, which was the main reason. 2, serous epithelium, endometrial metaplasia. Human embryonic stages, ovarian surface epithelium, peritoneum, the diaphragm and vagina, navel are body cavity metaplasia come, these organizations in the gonadal hormones, inflammation, mechanical factors stimulated to turn into another kind of organization, the same can metaplasia of the endometrium, uterine not, it becomes the ectopic endometrial. 3, blood lymph and benign transfer. This is a relatively rare disease causes. In the lungs, meninges, the pericardium, limbs and other remote endometriosis. through the blood circulation or the lymphatic system to transfer endometrial clastic stay in a certain organ or organization morbidity. 4, iatrogenic the endometrial transplants. This is a caused by human endometrial transplants so that certain parts were found to have cesarean section. Early pregnancy-dilatation and curettage OK, OK delivery of episiotomy, such as abortion in the process. Because uterine endometrium containing blood was planted in the abdominal cavity, abdominal and perineal anywhere. 5, immune defense functional limitations. Countercurrent with menstrual blood to the abdominal cavity endometrium, as a foreign body, activating the body's immune system, to mobilize large amounts of immune cells and body fluids surrounding the elimination, if the body immune deficiency, development will become endometriosis. 6, endocrine dysfunction. The ectopic endometrial, regardless of origin, its growth with changes in the ovarian endocrine, estrogen can promote growth, progesterone can inhibit it, the majority of patients with clinical found that the lack of progesterone and therefore contributed to the occurrence of the disease development. 7, genetic and physical factors. Clinical observation it was found that family history of breast cancer most people. Physical factors such as obesity and overweight, excessive length, have a certain relationship. Known more for the cause, the cause of several influences, can trigger endometriosis.

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