Gonococcal anal Proctitis

Albert outlined in 1897 in patients with urethral? Neisser, vaginal and neonatal eyes Pott found gonorrhoeae, it will be named as Neisseria gonorrhoeae Neisseria gonorrhoeae (Neisseria gonorrhoeae). After three years Leistikow Loffler and isolated and cultured in vitro success. Bumm in 1885, cattle or sheep serum on the solidification cultivate bacteria, and the vaccination of healthy people in the urethra also have the same symptoms, Neisseria gonorrhoeae, as the bacteria could only be established. But gonorrhea and chlamydia infection in the early 20th century, is still confused. Symptoms of lighter, urethral secretions thin they think is chronic gonorrhea, until the application of penicillin to cure gonorrhea, urethritis recognized this as another STD. Etiology and pathogenesis of human pathology is the only host gonococcus. Neisseria gonorrhoeae to lower non-pathogenic animals, the human body has repeatedly urethral contain gonorrhoeae Pott transplantation in the rabbit eye. trying to combine uveitis caused gonorrhoeae, always without success, to explain that human Neisseria gonorrhoeae lack of the ability to kill. So gonorrhoeae can infect people. For lower animals do not infringe capacity. Clinical manifestations were seen mainly in male homosexuality. Women own more from vaginal infection caused. Performance radiotherapy, pus it, congestive anal mucosa, purulent secretions, culture positive gonococcal. Censorship (1) Pap smears : urethral secretions from patients or cervical secretions, as Gram staining, in polymorphonuclear leukocytes find double Gram-negative cocci. Smear a large number of purulent secretions before the pure gonococcal urethritis patients, the positive rate of this method at 90% Initial diagnosis can be. Pharyngeal Gram-negative smears found not to mention the diagnosis of gonorrhea, because other bacteria Neisseria the hypopharynx is a normal flora. In addition to typical symptoms of smear-positive should be further checks. (2) The development of inspection : Neisseria gonorrhoeae diagnosis is important corroboration, the culture of the symptoms are very light or asymptomatic men Female patients were more sensitive method, as long as can be confirmed culture positive, the advent of genetic diagnosis before Culture of the World Health Organization recommended screening gonorrhea only way. Cultivate positive rate of 80% -95 m%, female 80 -90%. A treatment, treatment principles : (1) Early diagnosis and early treatment; (2) timely, adequate and regular medication; (3) In response to a range of conditions using different methods of treatment; (4) tracing of sexual partners, while treatment. 2, treatment programs : (1) gonococcal urethritis and cervicitis : Procaine Penicillin G, 4.8 million units to 100 ml of normal saline infusion; Ampicillin or a 4.0 g oral intravenous injection is also available; Amoxicillin 4.0g or Kingston service. To produce the enzyme penicillin Neisseria gonorrhoeae (PPNG), or to penicillin-resistant Neisseria gonorrhoeae. When penicillin-resistant Neisseria gonorrhoeae rate of 5% over the use of penicillin should peri tazobactam sodium. Another may choose to use other drugs; 1. Cephalosporins, ceftriaxone 3.0 g infusion, cefotaxime sodium 4.0g infusion. 2. Adriamycin-concept, also known as the leaching will rule, a 2g intramuscular injection, some people advocate women with a 4g intramuscular injection. 3. Quinolones : Ofloxacin, shouting Tarivid 600 mg, an oral, ofloxacin, 200 mg intravenous drip. Note : quinolone ban pregnant women and children. 4. Beta-lactamase inhibitor drugs and penicillin mixture, a new priority for the penicillin and ampicillin n oxide mixture. 1.5g an intramuscular injection, particularly for sterilization Jiashubatan sodium piperacillin sodium, 3.0 g an intramuscular or intravenous. Because gonorrhea patients with concurrent with chlamydia infection, We commonly used in the treatment of Ceftriaxone 3.0 g intravenous and oral azithromycin, or 250 mg roxithromycin, twice daily. (2) gonococcal pharyngitis : Ceftriaxone 3.0 g infusion; Or 250mg oral ofloxacin, three times a day, or sulfamethoxazole 1 g / time, twice a day, a total of 7. (3) gonococcal proctitis : Ceftriaxone 3.0 g intravenous, or Lok Shifu 3.0g infusion set, Gravit governance bacteria or 3.0 g infusion. (4) adult gonococcal ophthalmia, AS G1000 million units of penicillin intravenously once a day for a total of 5. (5) children gonorrhea ≥ 45kg weight in accordance with their adult dose administration. Weight "45kg of children by the following method of delivery : Ceftriaxone 125mg, one intramuscular injection; Le Shifu fixed or 25 mg / kg, an intramuscular injection; or spectinomycin and 40 mg / kg, an intramuscular injection.