Fatty liver will cause abnormal liver function

Fatty liver disease may be one or more abnormal liver function tests. Adult health examination found abnormal liver function, about 35% of fatty liver, therefore, Asymptomatic ALT (SGPT using old) increased the most common causes of fatty liver, but not hepatitis. Abnormal liver function and hepatic steatosis infiltration as the extent, scope and causes involved. Mild European allies orchestrated smashing Fei brother skull # distribution and the 19th seeds and chemical LT AST (SGOT using old), mild to moderately increased (non-general than the normal 2 to 3 times), non-alcoholic fatty liver appears AST / ALT ratio of less than I, while alcoholic liver lipid AST / ALT ratio greater than 2 often. GGT also increased alcoholic fatty liver is particularly high when, about 30% of Severe fatty liver disease can lead to different degrees of ALP increased. About half of these fatty liver disease to emerge Dye (indocyanine green) excretion of abnormal test. Serum bilirubin, albumin, PT usually no obvious changes. Severe chronic fatty liver disease are also sometimes there may be changes in plasma total protein and albumin / globulin ratio inversion, PT extended application of vitamin K can be corrected. But by liver biopsy confirmed the fatty liver, only 20% to 30% of the patients had one or more of the above indicators of abnormal laboratory examinations and therefore can not accurately reflect the availability of fatty liver and its extent. Fatty liver pathology What changed? Fatty liver is a common liver disease jurisprudence change is the liver toxicity of various injuries early performance. Hepatic fatty liver of gross morphology, histology and Asian micro-structures are undergoing a series of changes. (1) general morphological changes : liver appearance diffuse swelling, and the blunt edge of thick, smooth surface, such as the quality of dough, oppression Depression may arise when the surface, color or pale compared with greyish yellow, the plane was to be yellow or red light yellow, oily flu. Jackknife, hardness were slightly above normal, fatty flank contamination. (2) optical microscope : liver cells swollen and full of fat ranging from the size of vacuoles (lipids), Japan vacuoles were more than liver cells can be pushed aside. Several contain fatty liver cells rupture, forming fatty cyst, cyst rupture can cause inflammation. Light to moderate fatty degeneration in the center aggregated in the most obvious, the general no significant inflammatory response and cell necrosis. Severe patients throughout the liver parenchyma cells have fatty degeneration and limitations associated with mild inflammation and necrosis simple. Moderate and severe fatty liver associated with a certain degree of fibrous tissue hyperplasia of hepatic (liver fibrosis), with liver regeneration. Fatty liver cells bile canaliculi oppression, we can see cholestasis. Effective treatment after liver cells or cyst fat, liver cells return to normal. If the original inflammation or fibrosis, fat disappear in the short term after the remnants may focal inflammatory cell infiltration and fibrosis. (3) Observation : mild fatty liver visible fat stored in the cytoplasm without infringing mitochondria. Moderate and severe fatty liver and small bubble-type fatty liver fat micro-vesicles can be seen in the plasma bubble and endoplasmic reticulum were piled up, Gorky intimate with the accumulation of lipid droplets and inflating. Mitochondria can be increased, deformation, even rupture, transparent necrosis. Hepatic fatty liver What has changed? Fatty liver deposition of a large number of cells in fat, fatty liver cell degeneration, thus the normal liver structure changes have occurred. Visual observation of fatty liver morphology : liver Zhi uniform appearance was increased, and more without changing shape, blunt edge and thick, smooth surface, if the quality of dough, cut surface and the surface of red or yellow and white collars, greasy feeling. The optical observation can be seen under a microscope : small liver run inside and outside fat infiltration; Liver cells swell, It is with the size ranging from the fat particles, the nuclear pushed to the side, which is fatty cyst. Visibility fat infiltration in the liver tissue. Severe fatty liver, liver showed its mesh-like, do not see the normal liver cells and fat infiltration in the entire liver.