Cause of infertility five common genetic disease

Genetic diseases are the parents of reproductive cells, the sperm and eggs is carry an ill gene, and then-child transmission of the disease in male infertility diagnosis and classification. common people familiar with the factors of male infertility, male infertility and the right trigger genetic diseases have very little understanding in this, Shanghai Marriott hospital drugs such as Valium to introduce the five male infertility caused genetic diseases. (1) Cleanfelt's syndrome (Klinefelter levy, Klinefelter), the disease is more common in male newborns or about 1 / 500, Dr Klinefelter (Dr. Klinefelter) in the 1942 first described, so named. The disease is usually asymptomatic childhood, adolescence and symptoms, the typical clinical manifestations : limbs grow too long. Muscle Development worse, it is common to the female breast, facial and body hair sparse, small testes and hard, Visibility testicular fibrosis and microscope glass-like degeneration, the process of spermatogenesis serious obstacles or stop blood high FSH and LH, the lower gonadal function, multi accompanied by mental retardation and sexual dysfunction. This is because sex chromosome abnormalities caused by the incurable. (2) in patients with Turner's syndrome the most karyotype is 46, XY; Only a small number of chromosome mosaicism. Clinical manifestations of short stature, webbed neck, ears low position, shield-like chest, and cryptorchidism spermatogenic dysfunction, serum low androgen levels, the majority lost reproductive capacity. (3) Reversal of this syndrome patients with clinical manifestations of Cleanfelt's syndrome similar to the appearance of male men have psychological state, but small testes, no pubic hair or pubic scarce. Karyotype of 46, XY. (4) dynamic hysteresis cilia syndrome disease many consanguineous marriage family history, clinical manifestations of visceral anti-bit (eg : right-heart), bronchiectasis and chronic sinusitis, the sperm tail cilia movement disorders. Because these parts of the ciliary dyskinesia occurred. (5) cell only syndrome incidence of the disease is about 3%. Contour no congenital defects performance, but the lack of testicular germ cells, no sperm, increased serum FSH, but testosterone levels normal. In addition, some other genetic diseases caused by infertility, should also be attended to. Most of these patients have a close relative married to history, or living in remote mountain villages and water areas, often family history. require careful investigation, timely detection and treatment.