The etiology and coronary heart disease risk factors

The etiology of coronary heart disease is multifaceted, and the following major risk factor related. One, aged After the 40-year-old was particularly prevalent in the pathogenesis. Second, gender Women emerging from atherosclerotic lesions caused by heart, brain and peripheral vascular symptoms, often after menopause. This was mainly due to decrease of estrogen after menopause and decrease in those high-density lipoprotein. Third, blood pressure Sustained blood pressure increased significantly increased incidence of coronary heart disease. Hypertension can cause: ① intimal layer and endothelial cell injury, and low-density lipoprotein cholesterol easy invasive artery wall, as well as fiber hyperplasia thickening to the platelet and blood lipoprotein increased permeability of the release, which further stimulate smooth muscle cells value. ② vascular done to stimulate smooth muscle cell proliferation, the vascular wall elasticity of collagen and mucopolysaccharide increased; ③ enable smooth muscle cells within the lysosome increased arterial wall reducing cholesterol removal. Fourth, dyslipidemia and atherosclerosis Most closely related to the formation of high LDL hyperlipidemia, high blood cholesterol low HDL integration hyperlipidemia. However, some people think that increased VLDL and triglyceride can cause this disease. In regular physical activity and a small amount of alcohol, their HDL odious, atherosclerosis also see lower rates. 5. Smoking Smoking can cause carbon monoxide in the red blood cells increased arterial wall to insufficient oxygen; Prompted organizations catecholamine release caused platelet aggregation; Blood HDL to lowering the volume of the original protein. 6, diabetes Diabetic patients the incidence of coronary heart disease, myocardial infarction morbidity and mortality than those without diabetes, and incidence morning. Many diabetic patients with hyperlipidemia, or accompanied by increased blood and platelet factor VIII activity increased, this will accelerate atherosclerosis and thrombosis caused arterial blockage. 7, obesity Normal weight more than 20% of its increased incidence. Particularly significant increase in the short term, atherosclerosis deteriorating rapidly. 8. Physical activity Regular exercise to lower blood lipids, myocardial infarction and sudden death occurred less. 9, genetic Have high blood pressure, family history of coronary heart disease and diabetes, the incidence rate increased significantly. 10. Character Easily agitated, enterprise-and Victory heart disease type A personality easy. These risk factors for sustained hypertension, hyperlipidemia, diabetes and smoking.