Why easy cirrhosis of bacterial infection?

Patients with cirrhosis blood IgG content is not reduced, humoral immune function without abating. the general poor health, malnutrition significantly, often emerging cellular immune dysfunction and defense. causing high bacterial infections. This phenomenon is attributable to : (a) liver reticuloendothelial system phagocytosis and filter bacteria dysfunction : Kupffer cells and cells sinus gap is the main body reticuloendothelial cells. patients with cirrhosis of fibronectin (fibronectin) reduction, liver swallowed reticuloendothelial system dysfunction, coupled with cirrhosis portal lateral Circulation, the portal can bypass the liver cells into the body of the Organization cycle, leading to sepsis occurred. (2) the lack of complement components, and in the management role and chemotactic activity : complement components manufactured by the liver. serious liver cirrhosis and fulminant hepatic failure of the C3, C5, B and D factor in reduced lead complement system activated and alternative ways dysfunction. Complement activation is conditioning eating bacteria, cirrhosis, the weakened role of such conditioning. Complement also led to a lack of leukocyte chemotactic factor (C3aC5aC567) reduction, tablets of inflammatory cells to gather the chemotactic activity. (3) neutrophils and monocytes dysfunction : patients with cirrhosis of neutrophil adhesion in vitro dysfunction, the body of the chemokine activity weakened. Neutrophils not easy migration from within the capillary wall outside to the site of bacterial infection. Leukocytes sterilization also weakened, affecting serum complement active substances, cells lacking glutathione and superoxide the enzyme. In addition, the monocyte phagocytosis and bactericidal activity and kill bacterial cells weakened role.