Testicular feminization syndrome and infertility.

Ovarian is gonad organs, in view of child-bearing age, ovarian 2.5 ~ 5.0 cm long, 1.5-3.0cm wide. 0.6 ~ 1.5 cm thick. In normal ovarian within ovarian Waterloo. Ovarian the main function is generated and discharged egg, and steroid hormone secretion. If ovarian syndrome, or dysfunction of tumor, etc. affect human development, such as health and fertility. Syndrome testicular feminization of testicular feminization syndrome, male pseudohermaphroditism a, also known as the complete androgen insensitivity syndrome. Pathogenesis of patients -- male gonad that gonad testosterone. In the early embryo, the testicles secretion of testosterone, but within the target organ cells lack of androgen receptor, Testosterone is not right reaction, which is hindering the male genitalia and pubic hair development. After puberty, testicular development, the same time the secretion of estrogen, and the formation feminization role, breast development, other female genital development type. Make genital development and gonad of the opposite sex. So as male pseudohermaphroditism. Clinical manifestations -- the appearance of the female phenotype, were female genitalia-and is high, arm length, hand, foot huge. After adolescent pubic hair, breast development, pubic hair, armpit scarce or absent, uterine and tubal not been formed, labia minora poor development, vaginal short paragraph on the end of fertility, gonad often in the groin or abdominal cavity, sometimes to labia majora. Testicular appearance was normal, but not mature after adolescence, was naive. Absolutely not give birth. Auxiliary check for the disease -- X-linked recessive genetic disease, with genetic characteristics. Karyotype of 46, XY. Testicular tissue examination : Qu seminiferous tubules were reduced, the active support of the immature cells and reproductive cells, but no sperm production, stromal cell proliferation. Serum FSH and LH increase. Blood Testosterone and dehydroepiandrosterone Habitat male normal range, as diagnosed on the basis of this disease. Treatment of the patients -- women are accustomed to the environment, although not give birth, but they can marry. This great opportunity malignant testicle, pubic hair development should be made after orchiectomy, was given estrogen replacement therapy, there will be further feminization.