[Syphilitic cardiovascular disease pathogenesis and patholog

Syphilitic cardiovascular diseases result from syphilis entered the aortic adventitia trophoblast vascular cause chronic inflammation, vascular occlusion, Then aortic elastic middle layer of muscle fiber and necrosis, fibrosis, scar formation, resulting Yan aorta and aortic aneurysm, Coronary artery stenosis and aortic insufficiency and other diseases, the corresponding clinical performance. Also penetrated a few cases of myocardial. The disease acquired infections, infected more after 10-25 years before emerging cardiovascular clinical symptoms and signs. [Pathogenesis and pathological -- Treponema pallidum local Tienam through the human body, entering the lymphatic node and liver. spleen, heart, brain and other organs, due to the ascending aorta lymphoid tissue more spirochetes portion of the hilar lymph control, nurtured into aortic vascular adventitia and leads to chronic inflammation; Nutrition vascular endothelial cell proliferation and transparent degeneration, vessel occlusion, adventitial fibrosis artery, middle and elastic fibers of muscle damage, and plasma cell infiltration and partial necrosis. Fiber aortic intima thickening, later accompanied atherosclerosis. Lesions occur in the ascending aorta and aortic arch, light less involved descending thoracic aorta, carotid arteries and abdominal aorta, Yan syphilitic aortic intima or for a smooth bark-like folds, the majority of patients with aortic atherosclerosis. As the disease often involved or aortic root, will expand a bad aortic valve, aortic valve leaves separated junction, and the aortic valve insufficiency; Mr involvement aortic valve, the valve thickening, kink, make aortic insufficiency exacerbated, aortic elastic middle layer of muscle fiber necrosis and, The flexibility of artery walls disappear bulging outward, forming aortic aneurysms, aortic sinus lesions. aortic wall fibrosis can lead to coronary artery stenosis. Since coronary stenosis slow, it often collateral circulation, the less cause myocardial infarction, But angina still occur from time to time. Treponema pallidum very rarely penetrated the heart, Myocardial diseases mainly due to aortic valve insufficiency, or coronary artery stenosis caused myocardial hypertrophy or fibrosis. If accompanied by coronary atherosclerosis, and often can lead to myocardial infarction, myocardial degeneration gum extremely rare, Such lesions confined to the more septal left bundle-branch and the beam. Diffuse gum rare kind of change.