The liver fibrosis and cirrhosis treatment

Cirrhosis of liver injury in a variety of end stage, liver fibrosis and its original features. Liver fibrosis is due to the extracellular matrix formation and degradation of the imbalance between intrahepatic accumulation of fibrous tissue, many are surrounded by fibrous tissue regeneration of liver nodules caused extensive damage to the structure. Any damage the liver stable environment within the process, especially inflammation, toxicity damage, liver blood flow changes in the liver infection (virus, bacteria, spirochetes, parasites), congenital metabolic disorders material accumulated diseases, chemical substances such as alcohol and drugs, isoniazid methyl Dopa, Amiodaron long biliary obstruction and malnutrition, are the reasons for the incidence of the disease. Which chronic hepatitis and chronic alcoholism is a disease the most common. The disease belongs to the Chinese "hypochondriac pain," and "jaundice", "accumulation" and "bloat" areas. [Clinical] liver cirrhosis patients often District discomfort, pain, general weakness, loss of appetite, malaise and weight loss. can no symptoms for many years. If obstructed bile flow, there will be jaundice, itching, macular tumor. Malnutrition often secondary to anorexia, fat-absorption and lack of fat-soluble vitamins. More common symptoms of portal hypertension caused hemorrhoids, esophageal varices run lead to the end of gastrointestinal bleeding, also performance of liver cell failure, ascites or there portosystemic shunt brain injury. [Diagnosis] 1. The history of liver damage and related symptoms. 2. Signs can be enlarged liver which qulaity, liver palms and spider angioma, hepatosplenomegaly, abdominal varices, ascites. 3. Laboratory examinations : decreased serum albumin and prothrombin time, the small serum globulin can directly reflect liver function impairment. AST and ALT increased moderately often, normal or elevated alkaline phosphatase, biliary obstruction, often alkaline phosphatase increased. Often normal bilirubin, serum globulin increased. There are early pigment is cell anemia, and occasionally for the large cell anemia, thrombocytopenia, leukopenia. 4. Liver isotope scanning, x-ray examination, the other ultrasound examination, endoscopy and liver wear to provide a clear diagnosis support. 5. The disease takes and other reasons the liver size, splenomegaly, upper gastrointestinal bleeding, such as ascites differential. [Treatment] liver fibrosis and cirrhosis, in a sense could be reversed, cirrhosis of the late usually irreversible, more to symptomatic treatment-oriented. 1. Western medicine treatment (1) general treatment : The original treatment of disease etiology, out toxic drugs, alcohol, attention to nutrition (including vitamin supplements), to deal with complications. Add the proper blood albumin, used 20-40ml in 5% glucose for dilution,% solution static, two times a week. (2) drug treatment ① fatty liver drug resistance : as choline and methionine amino acid, or vitamin Be inositol. Other glucuronide within UB poison; Victoria propylamine liver cells have prompted new role. ② anti cirrhosis or liver fibrosis drugs : corticosteroids. with lower collagen MRI -- NA level and anti-inflammatory effects. Available prednisone 200 mg / day prednisolone 10-15mg / day. Penicillin serotonin can interfere with collagen cross-connect 1.5-1.8 g / day, four times preprandial taking. Colchicine can inhibit collagen microtubule polymerization of 1 - 2 mg / day. However, corticosteroids and long-term application of penicillamine high toxicity. In addition, the cable colchicine to reduce the accumulation of collagen role is controversial. The new formulations (r-IFN, ketoglutarate analogues and prostaglandin analogues) can reduce the formation of collagen, the discretion to choose. ③ for liver function serious obstacles, the general situation worse, can be used to promote the metabolism of drugs such as ATP20mg. Coenzyme A50 units, insulin 12 units and 10% potassium chloride common 10ml 10% glucose solution 500ml. intravenously once a day, 2 - 4 weeks for a course of treatment.