Infertility ovarian syndrome

Ovarian is gonad organs, in view of child-bearing age, ovarian 2.5 ~ 5.0 cm long, 1.5-3.0cm wide. 0.6 ~ 1.5 cm thick. In normal ovarian within ovarian Waterloo. Ovarian the main function is generated and discharged egg, and steroid hormone secretion. If ovarian syndrome, or dysfunction of tumor, etc. affect human development, such as health and fertility. Gonad ovary syndrome hypoplasia including simple gonad hypoplastic not with short stature, mixed gonad dysgenesis and Turner syndrome (Turner'ssyndrome). A pure gonad stunted, with short stature is not simply the gonad imperfecta, no abnormal, karyotype to 46, or 46 XX, XY. The appearance of female patients has emerged. (1) a simple XY gonads hypoplastic ??pathogenesis -- Under normal circumstances, Early embryos male hormone testosterone in the testicles and one vice renal inhibiting factor, former get kidney development of male reproductive system, such as the epididymis, vas deferens, the seminal vesicle, prostate, penis and scrotum. the latter prompted Deputy renal tube degradation. 46, XY simply Agenesis of the gonad patients, chromosomal genetic mutation, embryonic development is not in the testicles, not secretion of testosterone and vice renal inhibiting factor, as a result of renal tube degradation, the inability to male genitalia, and vice renal tube development, forming female reproductive system, the patients were female appearance, by way of life of women. Clinical manifestations -- primary amenorrhea; Internal and external female genitalia, poor development; Pubic, armpit less, not breast development; build and development may male hands; Turner syndrome lack the typical clinical symptoms. The disease can not bear children. Auxiliary -- karyotype 46, XY, sex chromatin check for (-) or (+). Low levels of estrogen and FSH significantly increased serum testosterone low. Treatment -- to try hormone replacement therapy. But patients with malignant transformation of the gonad chances, diagnosed immediately after surgical resection of bilateral gonad, after giving estrogen replacement therapy or medicine splenorenal two completed treatment. (2) XX simply gonad hypoplastic pathogenesis -- unknown pathogenesis. Clinical performance -- disease known subtypes of ovarian syndrome. Ovarian development, female genital dysplasia, no deformity and female pubic hair development worse, no short stature and Turner syndrome characteristics. Auxiliary -- karyotype 46, XX, blood estrogen levels low, FSH significantly increased. Treatment of reproductive function -- can not be built using only estrogen, Periodic artificial progesterone replacement therapy or traditional Chinese medicine. 2. Turner syndrome (Turner syndrome) ??pathogenesis -- also known as hypoplastic gonad , such as short stature associated with physical deformities or congenital dysplasia of ovarian syndrome. A normal female karyotype, 46, XX, ovarian development must have two X chromosomes of all genes, which prevent short stature and webbed neck at the gene on the X chromosome 3p. Cells divide, for some reason, sex chromosome separation, the formation of the zygote only one chromosome; or splitting process, the short arm of the X chromosome breakage or loss. Sex chromosome number or structure abnormalities, can occur in ovarian syndrome symptoms Clinical formed on the gonad congenital dysplasia or Turner syndrome. Ovarian only some parts of the white fibrous cords, no original follicle. Clinical manifestations -- primary amenorrhea, or the uterus without stunting growth, breast development, pubic hair, armpit scarce or absent. Short stature, adults rarely exceed 150 cm tall. More than half of the neck skin relaxation from ear to the mastoid Department acromion, webbed neck was 50%. Shields-like chest, late-time low, valgus elbow. Nipple at the clavicle midline, and both nipples distance, 4,5 metacarpal shorter. Often with aortic stenosis and urinary system abnormality. Reports about every 2,500 girls have a breast cancer. The disease without reproductive function. Auxiliary -- karyotype 45, X, the most common type of chimeric 45, X/46, XX. Low levels of estrogen and high FSH. Treatment of the patients -- can not be established reproductive function. Estrogen therapy can promote breast development, pubic hair, armpit slight growth, stimulate endometrial hyperplasia, a withdrawal bleeding properties, similar to menstrual. Another estrogen therapy is also beneficial to life, the patients have a good role euphoric and comfort. Currently advocated artificial estrogen and progesterone therapy cycle to induce cyclical bleeding, one of the patients is a psychological comfort, the other because of endometrial regular exfoliation, to prevent endometrial cancer. Long-term use of estrogen, induced endometrial cancer risk. Short stature is reported using Nandrolone phenylpropionate treatment, with good results. Right chimera containing the Y chromosome, surgical resection should be bilateral gonad to prevent malignant transformation.