Friday, January 11, 2008

Hepatitis C infection and clinical performance

A few years, a large number of studies have shown : Hepatitis C is a chronic liver disease one of the main reasons it easier than chronic hepatitis B. About 1 / 2 of the patients with hepatitis C develop chronic hepatitis, of which about 30% of the development of cirrhosis; hepatitis C is also one major cause of hepatocellular carcinoma. Nearly two-three-year study showed that hepatitis C is one common viral hepatitis. Hepatitis C transmission and clinical performance similar to hepatitis B, hepatitis C and blood relationship is even closer. More than 50% of hepatitis C patients have blood (or plasma) history. If the input blood with hepatitis C virus, after a period of latency (generally one to two months), then there hepatitis symptoms (fatigue, anorexia, jaundice, there will be some) and abnormal liver function. The patient's blood can be detected in anti - hepatitis C virus-specific antibody (anti-HCV) and (or) Hepatitis C virus ribonucleic acid (HCV-RNA positive). Because hepatitis C virus infection in vivo anti-HCV in blood and the time later, while HCV-RNA produced earlier, and HCV-RNA expressed in the liver hepatitis C virus replication active, therefore HCV-RNA can be more accurate and earlier diagnosis of hepatitis C. Generally, only the acute symptoms of hepatitis C minor, the general security Jiangmeiling treatment, the condition improved faster than hepatitis B, but illness easily become chronic and repeated if the chronic hepatitis B infection on the basis of hepatitis C infection, the original will enable the increase of hepatitis, or even the development of severe hepatitis or accelerate the development of cirrhosis. So doctors should attach great importance to the hepatitis C early diagnosis, treatment and prevention. Currently, foreign and domestic studies have shown : the interferon B hepatitis C have more good effect : After the formal 3-6 months after interferon treatment, about 50% of patients resume normal aminotransferase, HCV-RNA negative conversion (shown by the hepatitis C virus and inhibit addition), anti-HCV titers were also reduced. Division I the past two years, use of imported or domestically produced a lot of interferon therapy in patients with hepatitis C, efficacy than satisfactory. Since at present there are no vaccine for hepatitis C vaccine-preventable application, the most important pre-HCV measures : First, the screening of blood donors. abnormal liver function anti-HCV positive, unable to donate. Two is strictly controlled blood transfusion indications I would not be transfusion.

No comments: