Saturday, January 12, 2008

Cirrhosis of nutrition therapy


The liver is the metabolism of nutrients to vital organs. Patients with liver cirrhosis, there will be sugar, protein, fatty acid synthesis and metabolism disorders, and anorexia, vomiting, diarrhea digestive dysfunction, and a large number of drainage ascites, gastrointestinal bleeding, bacterial peritonitis other complications occurred, patients in the nutritional status of further deterioration of the performance of stored energy decomposition of the body, fat oxidation and decomposition increase protein, increased mobilization of glycogen, an increase of the incidence of complications. caused liver function deteriorated further, the survival rate dropped. Therefore, the patients with cirrhosis targeted parenteral nutrition therapy is essential. Each of patients with chronic liver disease are associated with varying degrees of malnutrition, nutritional imbalances are cirrhotic patients in the early characteristic performance, Synthesis and serious metabolic disorder will increase the incidence of complications caused further deterioration of liver function, affects the prognosis, the survival rate decline, therefore, to be conducted in patients with cirrhosis targeted, reasonable parenteral nutrition therapy can improve liver function, prevention of complications. In patients with cirrhosis, the total energy consumption With the progression of volatility, the metabolic pathways for individual differences, there are very large differences therefore nutritional support programs need individualized. Patients under the specific circumstances of daily given a certain amount of sugar, the long-chain lipid emulsions, branched-chain amino acids substances, to reduce the negative nitrogen balance. However, the long view, right hepatic dysfunction intravenous fat emulsion is not appropriate and Monosaccharide only to the parenteral nutritional support, but some scholars, giving patients with cirrhosis, including fat emulsion of parenteral nutrition, it is not deteriorating liver function, it is helpful to improve liver function and regeneration. The patients had varying degrees of liver dysfunction, parenteral nutrition support for three weeks, the treatment group ALT and total bilirubin, PPGB2h dropped AST, ALB, FBG, CHOL, TG did not change; the control group TBIL and ALT levels remained high, and ALB is markedly lower. Suggested fat emulsion help restore liver function, particularly medium - and long-chain lipid emulsion can be directly used without the liver in which storage. As bad liver function, reduced ability to use glucose, liver can not fully utilize glucose as a substrate for energy, thus monosaccharide treatment is not conducive to the recovery of liver function, application fat emulsion can reduce the importation of glucose, avoid high glucose-stimulated insulin secretion, is conducive to correcting glucose metabolism disorders. Foreign literature, patients with cirrhosis of the fat clearance capability. The treatment group did not give fat emulsion caused TG, CHOL levels to rise. The study shows that patients with cirrhosis of the targeted parenteral nutrition is very necessary, it also uses for the fat emulsion can improve liver function and glucose metabolism disorders, and it will not cause lipid metabolism disorders, is safe, reliable.

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