Cholestasis therapy

(1) a basis for treatment. Vitamin supplements can be given vitamin K110mg, a daily intravenous infusion or intramuscular injection; vitamin A25000 units, 2,500 units of vitamin D, the weekly l ~ 2nd intramuscular injection; vitamin E supplement from the gut may, in part to correct the nervous system symptoms, there is no guarantee that the blood or tissue of the appropriate vitamin E concentration, they are normally intramuscular injection of 0.5% acetic acid solution vitamin E oil, every one to two times. each 2ml 1 ~ (5-10mg). 2. Calcium supplementation adult acute cholestasis calciprivia generally not the clinical manifestations, but infant and adult chronic cholestasis and chronic severe hepatitis should add calcium. The first major infusion of diluted acid 1g glucose after oral 0.5g, two times daily. 3. Add fat in the acute phase should limit fat intake, daily food fat content should not exceed 40g, dissipated as jaundice, fat content can be gradually increased to 40 ~ autumn / d. When the long-term severe jaundice, should be given easy absorption of medium-chain fatty acids, because of this fatty acid in the absence of acid circumstances also be absorbed. 4. Limit cholesterol absorption of cholesterol into bile acid oxidation part, the part of a prototype human bile into the molecular groups. If the cholesterol content of food, bile cholesterol increases, the viscosity increased bile, bile flow reduction. It is of cholestasis patients should limit the intake of cholesterol. 5. Supplementary heat should be given high calorie, every major 8400 ~ 12600kJ. Right serious gastrointestinal symptoms can be 10% of intravenous glucose solution, symptoms improved suspended. not as a routine treatment. Chronic hepatitis, cirrhosis with cholestasis, an appropriate reduction in protein quality, in order to prevent ammonia poisoning. 6. Fill-energy liver cells of the bile acid uptake, metabolism, and the secretion of bile flow and so dependent on energy metabolism. Energy supply of adenosine triphosphate mainly in the liver mitochondria synthesis, cholestasis mitochondria are morphological and functional changes. In vitro experiments show that acid can inhibit mitochondrial respiratory chain of electron transfer, so ATP synthesis, it should be added triphosphate with adenovirus, such as coenzyme A mixture of energy. 7. Added Valley-glycosides peptide drug metabolism process needs an SH-based. In addition, an SH-can directly affect the metabolism of prostaglandins, the right drug cholestasis should complement the SH-1, general users Valley-glycosides 1200 peptide / d intravenous drip.