Activated Carbon blood perfusion therapy for the treatment o

Right severe hepatitis, especially acute liver failure patients. recent trends in the treatment of the design of a temporary replacement to liver function in vitro device, or called "artificial liver" Duguoweijianji to assist patients, the liver from pathological conditions and regeneration. Activated Carbon blood perfusion therapy is to direct blood contact with the activated carbon. Adsorption and thereby remove blood of the patients with hepatic coma of toxic substances. In 1974 it was used in 22 cases of grade IV patients with hepatic coma and consciousness recovery rate was 50% survival rate was 45.5%. However, in clinical trials was found in the blood leukocytes and platelets are activated carbon adsorption after refractory hypotension, granular activated carbon and release into the blood cause pulmonary embolism. Also, because non-specific activated carbon adsorbent, which cleared both molecular substances, such as mercaptan, α-amino butyric acid, ethanol, Scented group amino acids, liver regeneration inhibitors, membrane Na +-K +-ATPase inhibitor, , and other potential toxins, can remove epinephrine, T3, aldosterone, insulin and the body of useful material. These important material depletion will affect liver function and hepatic failure coma recovery. Later, someone study the application of the "artificial cell" theory, the design of a biocompatible polymer reflected in the activated carbon particles, embolization can be eliminated and reduce platelet consumption; It was also reported with PGI2 pHI2 to be effective in controlling blood perfusion during platelet cohesion hypotension. In recent years, many developed the albumin-lipid activated carbon material which is conducive to the removal of toxins, , and is examining selectively remove the pathological antibody complexes and the immune new adsorbent. In short, the new technology means activated carbon in an attempt to make the law more blood perfusion perfect, will the average survival rate from 30% to 70%.