Drug-induced meningitis alert

Generally believed that bacteria, viruses and lead to meningitis is the culprit. However, some drugs can also cause meningitis, medically known as the "drug-induced meningitis" or "aseptic meningitis." In recent years, clinicians found that some patients in the use of certain drugs will be similar to meningitis symptoms, such as fever, headache, stiff neck, lethargy, the sense of ambiguity, and even coma. Some patients showed a visible conjunctival hyperemia, nausea, vomiting, sweating, body pain and meningeal irritation symptoms of some patients neck pain, limb tendon reflexes symmetry hyperthyroidism, or convulsive spasm limbs, shortness of breath, depending on Fuzzy, that the proliferation of body rash. The peripheral blood and cerebrospinal fluid examination, can be found in erythrocyte sedimentation rate accelerated increase in cerebrospinal fluid interleukin such as abnormal changes, but found no special bacterial culture. The experts found that it is drug-induced meningitis. According to clinical statistics show that, ibuprofen, sulfamethoxazole, trimethoprim amine pyrimidine, caused the most reported drug-induced meningitis. In addition, the non-phenazopyridine, Tolmetin, immunoglobulin, cytarabine, isoniazid, penicillin, azathioprine, diclofenac sodium, pipemidate, also cause meningitis reported. Drug-induced meningitis mechanism is not yet known, but scholars tend to drug-induced allergic reaction, the reasons are: meningitis medication after clinical signs and symptoms of the short time interval, drug excited shorter latency, and severity of the increase, suspended after drug treatment without symptoms and signs quickly returned to normal. CSF after the drug stimulated immune complexes showed positive results, immunoglobulin synthesis rate increase, presumably because of drugs as a hapten combined with the protein to form a security antigen recognition by the immune system, thereby activating the brain sheath in the original autoantibodies in the immune response. Drug-induced meningitis occurs in adults and children is extremely rare, more women Most of cotrimoxazole such as meningitis caused by drug-induced occurred in almost all women, which may be related to the level of frequency of administration. Drug-induced meningitis diagnosis of a clear, we must immediately stop. Usually in the 12 ~ after treatment within 48 hours of their own rehabilitation. Only a small number of people needed antibiotics, hormones such as a symptomatic treatment. Patient prognosis is good, generally without sequelae.