Hyperlipidemia clinical performance

Hyperlipidemia main clinical manifestations including two major aspects : (a) lipid deposition in the dermis caused by the yellow tumor; (2) in vascular endothelial lipid deposition caused by atherosclerosis, coronary heart disease and have other peripheral vascular disease. As hyperlipidemia yellow when the tumor incidence rate is not very high, Atherosclerosis the incidence and development will take quite a long time, Therefore, the majority of patients with hyperlipidemia no abnormal signs and symptoms found. And patients with hyperlipidemia often is conducting biochemical blood tests (serum cholesterol and triglyceride) were found. A yellow tumor (lesion) is a variation of limitations skin LAI tabs, its color can be yellow, orange or brown-red, shaped nodules, papules or plaques shape, texture general softness. Mainly due to the dermis swallowed lipid concentration of macrophages (foam cells), also known as yellow caused by the tumor cells. According xanthoma the shape, location, and can be divided into the following categories : (a) xanthoma tendon (tendon lesion) is a special type of tumor nodules yellow, in the tendon location, common in the Achilles tendon, hand or foot stretch tendon, knee and shoulder rectus femoris tendon triangular or anywhere. Round or oval quality Scleroderma under nodules on the skin with adhesive, clear boundary. This xanthoma is often familial hypercholesterolemia more characteristic performance. (2) palmar crease xanthoma (palmar crease lesion) is a palm occurred in the Department of lines Flat-yellow tumor, was mild orange tabs, located in the palm and fingers between crease Department. Such xanthoma in the diagnosis of familial abnormal beta-Hyperlipoproteinemia a certain value. (3), nodular yellow (tuberous lesion), the slow occur in the physical side of the sun, such as the elbow, knee and knuckle stretch Office and the hip, ankle, buttocks and other parts. For a round nodule, sizes, borders clear. Early texture of a soft, late because of injury fibrosis, texture stiffen. Such xanthoma mainly in the family abnormal beta - lipoprotein familial hypercholesterolemia or hypercholesterolemia. (4), Tuberous measles xanthoastrocytoma (tuberous eruptive lesion) occurs in the extremities elbow extensor side and buttocks, the lesions often in the near future bulk emergence was nodular integration trend measles-like yellow packets around the tumor often nodular xanthoma. Tumors of the skin was orange, accompanied inflammatory basement. This xanthoma mainly in the family abnormal beta-Hyperlipoproteinemia. (5), measles xanthoastrocytoma (eruptive solitary) for the performance of needles or Commelina benghalensis size papules, brown or orange color associated with inflammatory basement. Sometimes oral mucosa may also suffer. Mainly in hypertriglyceridemia. (6), flat xanthoma (xanthelasma) found in eyelid weeks, there eyelid called xanthomas, is the more common of a yellow tumor. Performance of the eyelid occurred around Orange slightly out of the flat surface papules or flake - like tumor, a well-soft texture. Generalized the ramifications, neck, trunk and limbs of flat yellow or brown papules, a few millimeters to a few centimeters in size. clear boundary, surface smoothing. Such xanthoma various hyperlipidemia common, but can also be found in normal blood lipids. These different forms of yellow tumor can be seen in different types of hyperlipidemia. At the same types of hyperlipidemia who can arise in many forms of xanthoma. As effective lipid-lowering therapy, the majority of xanthoma can gradually dissipated. In addition to various xanthoma, there are two signs also help in the diagnosis of hyperlipidemia, and lipid corneal arch hyperlipidemia fundus changes. Bow cornea (corneal ARCUS) also known as the old ring, if found in the following 40 years, mostly associated with hyperlipidemia, familial hypercholesterolemia most common, but not very specific. Lipid hyperlipidemia fundus (retinal lipemia) are a result of triglyceride-rich lipoprotein particles Shen Fundus plot in the small arteries caused due to light scattering. often severe hypertriglyceridemia and was accompanied chylomicronemia performance characteristics. In addition, severe hypercholesterolemia especially homozygous familial hypercholesterolemia, there will be more migratory arthritis. But this situation is rare, and most of arthritis self-limited. Obvious hypertriglyceridemia can cause acute pancreatitis, should draw attention.