Chronic atrophic gastritis Diagnosis

Chronic atrophic gastritis no specific clinical manifestations, the diagnosis of chronic atrophic gastritis associated with clinical manifestations need auxiliary examination, especially for gastric endoscopy and biopsy. Below systematically introduced chronic atrophic gastritis diagnosis: (1) clinical manifestation: mainly anorexia, nausea, gas, or upper abdominal Duntong Baozhang, in a small number of patients can upper gastrointestinal bleeding, suffering from weight loss, anemia, a crisp, Guayan nipple or tongue atrophy. (2) laboratory ① gastric analysis: A type of multi-CAG acid-free or low-acid, B-CAG patients can be normal or low acid. ② Pepsinogen Testing: pepsin secretion, which used master cells, chronic atrophic gastritis, in the blood and urine of pepsinogen levels decreased. ③ Determination of serum gastrin: gastric antrum gastrin secretion of G cells. Type A CAG patients, serum gastrin often significantly higher in patients with type B CAG antral mucosal atrophy, a direct impact on the secretion of gastrin G function, normal serum gastrin. ④ immunological tests: parietal cell antibodies (PCA), which factor antibody (IFA), gastrin antibody-secreting cells (GCA) determination can be used as chronic atrophic gastritis and its sub-aided diagnosis. (3) X-ray inspection: X-ray stomach barium meal examination majority of patients with atrophic gastritis without abnormal findings. Gas can show that the double-contrast barium gastric mucosal folds flat, thinned, the greater curvature of the stomach mucosal folds serrated thinned or disappeared, fundus smooth, inflammation of the gastric antrum was serrated or mucosa can be rough, such as performance of chaos . (4) endoscopy and biopsy: endoscopy and biopsy is the most reliable method of diagnosis. Gastroscopic diagnosis should include lesions and atrophy of intestinal metaplasia and dysplasia level. Observation of direct observation of the mucosa atrophic gastritis sustained pale or gray, thinning or folds flat. Mucosa may be in the red-and-white, scattered in serious white plaque. Mucosal vascular exposed to the characteristics of atrophic gastritis, we can see the red mesh small arteries or capillaries, severe chronic atrophic gastritis, there are epithelial cell proliferation or formation of small particles larger nodules. Also mucosal erosion and bleeding. Gastric biopsy mainly varying degrees glands shrink and disappear, replaced by pyloric glands or intestinal metaplasia adenovirus metaplasia, interstitial inflammation infiltration significantly.