Renal insufficiency drug should be cautious

Patients Zhang, 45 years old, because of bronchitis in the unit clinic for a routine dose intramuscular kanamycin. For the first five days, there appeared Zhang, 29,000 symptoms. 8 days, kidney function, according Zhang condition has deteriorated as uremia. Questioning history, Zhang, suffering from chronic nephritis, recently appears mildly lower extremity edema. This shows that the drug has already Zhang renal insufficiency, intramuscular kanamycin further damage to the function of the kidney. Aminoglycosides (Gentamicin, tobramycin, kanamycin), mainly through the kidney excretion. When human renal dysfunction, even by conventional-dose application of these drugs, kidney function may deteriorate rapidly developing uremia, or even life-threatening. Excessive, frequent drug abuse and other acts will lead to excessive concentration of drug in vivo, and even drugs in the kidney occurred crystallization immune complex deposition phenomena affect renal function. For example, it can lead to renal toxicity of the drug streptomycin, griseofulvin, if easily lead to excessive use of larger changes in urine, oliguria, no urine or urine increased, the patient suffered from edema, hypertension, hyperkalemia, testing, will have serum urea nitrogen, such abnormal creatinine increased renal damage drug performance. So that drug abuse is caused liver and kidney damage drug prices. Renal dysfunction in patients with medication, the first to use good effect on renal function in a small drug. Second, the use of renal excretion of the drug, it must comply with the medication as directed, not to their own decisions. Third, the process of emerging drug adverse reactions, should tell the doctor, timely reduction or suspension of renal function affecting the kind of drug. Fourth, those who need long-term medication, often to the hospital to detect drug concentration. Fifth, pay attention to the interaction between drugs, to prevent some kind of drug efficacy or side effects due to the impact of other drugs and change. Sixth, the process of using regular checks on the liver, renal function, careful observation of their original disease has there been any change.