Friday, January 11, 2008

Nephrotic syndrome patients how antihypertensive treatment?

Patients with nephrotic syndrome about half had mild hypertension, edema or mitigate am able to return to normal, it may, mild hypertension treatment. If the blood pressure in 21.3 / 13.3kPa above and swelling after the restoration of normal blood pressure, antihypertensive treatment should be taken. commonly used anti-hypertensive drugs and usage are as follows : (1) angiotensin-converting enzyme inhibitors : the antihypertensive drugs are the main mechanism by inhibiting angiotensin converting enzyme activity, and lower levels of angiotensin II, diastolic small arteries to buck purpose. Because of this right kidney disease caused increased renin secretion caused by renal hypertension good antihypertensive effects, in addition, there certainly slow down the deterioration of renal function, lower urinary protein and reduce the role of glomerular sclerosis, as they are commonly used in clinical. Captopril/Si-MCM-41 : Oral 1st 25 ~ 50 mg three times a day. benazepril (Lotensin) : 1st 10mg oral, once a day, according to conditions to 40mg per day. (2) calcium antagonist : Many studies have proven that the drugs except hypotensive effect, there delay kidney function role. nifedipine : Oral 1st 5-10mg daily 2-3 times. amlodipine (Norvasc) : 5 mg once daily, the biggest daily dose of 10 mg and oral. (3) p-blockers : drugs except by reducing cardiac output and hypotension, there reducing the role of renin, the renin-dependent hypertension better efficacy, and without prejudice to renal blood flow and glomerular filtration rate. US Metoprolol : Oral 1st 50 ~ 200 mg, once daily. Atenolol : Oral 1st 50 mg, once daily. (4) expansion of vascular drugs, hydralazine Prazosin etc. can be chosen, the former general 200mg daily. the latter is usually a daily 6-1.

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